Tuning the redox properties of the titanocene(iii)/(iv)-couple for atom-economical catalysis in single electron steps

TitleTuning the redox properties of the titanocene(iii)/(iv)-couple for atom-economical catalysis in single electron steps
Publication TypeJournal Article
Year of Publication2016
AuthorsGansauer A., Hildebrandt S., Vogelsang E., Flowers, II R.A.
JournalDalton Transactions
Volume45
Issue2
Start Page448
Pagination4
Date Published11/2015
Abstract

Radical-based transformations are an attractive target for the development of catalytic processes due to ease of radical generation, high functional group tolerance and selectivity of bond-forming reactions. In spite of these appealing features, the potential of radicals as key intermediates in catalysis remains largely untapped. Herein we present recent work that exploits the innate ability of titanocene-based catalysts to undergo both oxidative addition and reductive elimination in single electron steps. We further demonstrate that tuning the redox properties of the titanocene-based catalyst can be used to develop efficient catalytic free radical processes including tetrahydrofuran synthesis, and radical arylation.

URLhttp://pubs.rsc.org/en/Content/ArticleLanding/2016/DT/C5DT03891J#!divAbstract
DOI10.1039/C5DT03891J